New Scientific Knowledge & Development

Topic	Replies	Views	Activity
How to avoid NDMA in Metformin? (In press) Back in October 2020, we saw an increased concern about the potential presence of NDMA in Metformin. @trust_user_a @trust_user_b @trust_user_c “As of October 2020, EMA and the national competent authorities are asking …	3	980	August 22, 2022
About the New Scientific Knowledge & Development category	0	343	April 14, 2021
🇯🇵 Current Nitrosamine Landscape in Japan?	90	6658	April 22, 2024
Clinico-pathological correlations after intake of potentially nitrosamine/ NDSRIs contaminated drugs NDSRI	1	164	April 14, 2024
Are nitrosamines the connecting link or one of the connecting links between the concepts of phototoxicity and photocarcinogenicity due to the intake of a contaminated medication according to the 2019/ 2023 FDA list?	40	638	April 14, 2024
Nitrosamines: A new systematic review Drug_Substance_APIs , NDSRI , featured	11	2252	April 14, 2024
SOT posters and talks, (shared posters -update)	3	383	April 10, 2024
1st release of Lhasa 'Complex Nitrosamines' data sharing initiative	6	932	March 31, 2024
Antioxidant as a risk mitigation strategy NDSRI	5	409	March 28, 2024
Acceptable Intakes (AIs) for 11 Small molecule N-nitrosamines (NAs) -Pub	17	1985	March 28, 2024
Lack of effect of antioxidants on Biopharmaceutics Classification System (BCS) Class III drug permeability -Pub Excipients	1	334	March 13, 2024
Role of Carbonyl Compounds for N-Nitrosamine Formation during Nitrosation: Kinetics and Mechanisms	0	278	March 2, 2024
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth NDSRI	3	260	February 24, 2024
Discussion on Cleaning Validation Requirements for Nitrosamines Manufacturing , NDSRI	2	325	February 14, 2024
In Silico Prediction of N-Nitrosamine Formation Pathways of Pharmaceutical Products -Pub	0	407	February 8, 2024
Metabolic activation of short-chain alkyl N-nitrosamines using Aroclor 1254 or phenobarbital/beta-naphthoflavone-induced rat or hamster S9 – a comparative analysis -Pub	4	362	February 2, 2024
Formaldehyde Catalysis of Nitrosamine Formation	1	306	February 1, 2024
📚 OPRD Special Issue on Nitrosamines -Pub	13	1915	January 23, 2024
AMES Test Study Designs for Nitrosamine Mutagenicity Testing -Pub	1	421	January 23, 2024
Bumetanide as a Model NDSRI Substrate: N-nitrosobumetanide impurity formation and its inhibition in bumetanide tablets -Pub	2	716	January 16, 2024
New paper - Use of molar, instead of weight-based, safety limits	16	2131	January 7, 2024
N-nitroso Torasemide Impurity formation and control Drug_Substance_APIs , NDSRI	23	1477	January 5, 2024
Formation of N-Nitrosamines by Reaction of Secondary Dialkylamines with Trace Levels of Nitrite in Aqueous Solution: An Automated Experimental and Kinetic Modeling Study Using Di-n-butylamine	2	849	December 30, 2023
N-nitrosamines considerations for Inhalation products	10	775	December 24, 2023
N- NITROSO DESMETHYL LOPERAMIDE is it possible?	4	372	December 18, 2023
Redefining Nitrosamine Risks: A Fresh Perspective on Pharmaceuticals -Pub Drug_Substance_APIs , NDSRI	16	1876	December 17, 2023
🙋‍♂️ Citizen Petition to FDA on Sitagliptin	19	2256	December 13, 2023
Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation NDSRI , featured	11	1781	December 5, 2023
New data released into Lhasa Carcinogenicity Database	1	609	November 17, 2023
A new root cause? NOx	13	1198	November 17, 2023

How to avoid NDMA in Metformin? (In press)

Back in October 2020, we saw an increased concern about the potential presence of NDMA in Metformin. @trust_user_a @trust_user_b @trust_user_c “As of October 2020, EMA and the national competent authorities are asking …